Efficacy
Budesonide has a faster pharmacological onset of action than beclomethasone and fluticasone
Pulmicort® Respules® effectively relieves asthma symptoms1
Pulmicort® Respules® is associated with a reduced risk of future exacerbations
This study used administrative claims data from Florida Medicaid (approximately 1.3 million members) to compare the risk of having a repeat asthma-related hospitalisation or ED visit by asthma medication class. It also evaluated the relationship between asthma medication adherence level and repeat asthma hospitalisations or ED visits in this same population of children. The data included membership information and pharmacy, inpatient and outpatient medical service claims from January 1998 through June 2002.
A total of 10,976 children met the inclusion criteria (Medicaid members who were eight years of age or younger as of January 1999, and had at least one claim for an inpatient or ED visit with a primary diagnosis of asthma between January 1999 and June 2001). The first asthma exacerbation (defined as a hospitalisation or ED visit for asthma) that occurred between January 1999 and June 2001 was identified as the index event for each patient. Claims data for each patient were examined from 12 months before through 12 months after the index event
References
- Edsbacker S, Johansson CJ. Airway selectivity: an update of pharmacokinetic factors affecting local and systemic disposition of inhaled steroids. Basic Clin Pharmacol Toxicol. 2006;98(6):523-36.
- Mendes ES, Pereira A, Danta I, et al. Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids. Eur Respir J. 2003;21(6):989-93.
- Horvath G, Wanner A. Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma. European Respiratory Journal. 2006;27(1):172-87.
- Kemp JP, Skoner DP, Szefler SJ, et al. Once-daily budesonide inhalation suspension for the treatment of persistent asthma in infants and young children. Ann Allergy Asthma Immunol. 1999;83(3):231-9.
- Baker JM et al. Pediatrics 1999; 103(2):414—421.
- Camargo CA Jr, Ramachandran S, Ryskina KL, et al. Association between common asthma therapies and recurrent asthma
- exacerbations in children enrolled in a state Medicaid plan. Am J Health Syst Pharm. 2007;64(10):1054-61.