SUPPORTING RESOURCES
Peer-developed educational materials
ANIMATION
Identifying Low Levels of HER2 Expression in Breast Cancer
Short animation which describes CAP’s 2023 updated reporting template for HER2-low breast cancer and best practices for pathologists when reviewing these cases. (1.5 mins)
ANIMATION
Recognizing HER2 staining patterns at the low end of the spectrum
A short animation, discussing best practice recommendations for scoring HER2 by IHC with Dr. Feldman. (4 mins)
DOCUMENTARY
The significance of HER2
Dr. Marilyn Bui, pathologist, and Dr. Hope S. Rugo, oncologist, discuss the evolution of HER2 as a breast cancer biomarker in this mini documentary-style film. (19 mins)
ANIMATION
Lives behind slides
This short animation depicts patients with breast cancer, whose lives are impacted by their HER2 status. (2 mins)
MICROSCOPY SERIES
Microscopy review:
Slide validation
Dr. Bui discusses specimen requirements and recommendations to reduce pre-analytical variables. (17 mins)
MICROSCOPY SERIES
Microscopy review:
Approaching the scoring
Dr. Tozbikian demonstrates current approaches to HER2 IHC scoring. (17 mins)
MICROSCOPY SERIES
Microscopy review: Areas of diagnostic pitfalls
Dr. Hicks highlights considerations when interpreting HER2 status. (19 mins)
MICROSCOPY SERIES
Microscopy review: Correlating interpretation with clinical history
Dr. Feldman discusses histopathologic findings in view of the clinical background. (15 mins)
E-LEARNING
From past to present: The significance of HER2 in breast cancer
In the first session of this three-part program, Dr. Wei explores the spectrum of HER2 expression with slide reviews from Dr. Krishnamurthy and Dr. Wen. (48 mins)
E-LEARNING
Consistency with practice: Standardizing the approach to HER2 IHC scoring
Dr. Hicks discusses the importance of pre-analytic, analytic, and post-analytic variables. Dr. Khoury and Dr. Tozbikian review artifacts and indeterminate staining patterns. (57 mins)
E-LEARNING
Challenge accepted: Best practices for scoring HER2 across the spectrum
Dr. Jaffer provides guidance on recognition of HER2 staining patterns and heterogeneity. Dr. Krishnamurthy and Dr. Bui present challenging HER2 IHC cases. (60 mins)
E-LEARNING
Interpreting HER2 in breast cancer: USCAP course summary
Summary documents of the USCAP e-learning program Interpreting HER2 in breast cancer: A full spectrum of possibilities.
DOCUMENTARY
The significance of HER2: Trailer
A short preview of a mini documentary-style film presented by Dr. Marilyn Bui and Dr. Hope S. Rugo. (2 mins)
E-LEARNING
Topic 1: Clinical innovation across the HER2 pathway
Dr. Krishnamurthy presents the evolution of HER2 in clinical practice. (7 mins)
E-LEARNING
Topic 2: The spectrum of HER2 expression
Dr. Tozbikian reviews current HER2 guidelines and the significance of discrete HER2 IHC scoring. (9 mins)
E-LEARNING
Topic 3: Overcoming challenges in assessing HER2 expression across the spectrum
Dr. Hicks highlights best clinical practices for differentiating low levels of HER2. (11 mins)
ANIMATION
Identifying Low Levels of HER2 Expression in Breast Cancer
Short animation which describes CAP’s 2023 updated reporting template for HER2-low breast cancer and best practices for pathologists when reviewing these cases. (1.5 mins)
ANIMATION
Recognizing HER2 staining patterns at the low end of the spectrum
A short animation, discussing best practice recommendations for scoring HER2 by IHC with Dr. Feldman. (4 mins)
DOCUMENTARY
The significance of HER2
Dr. Marilyn Bui, pathologist, and Dr. Hope S. Rugo, oncologist, discuss the evolution of HER2 as a breast cancer biomarker in this mini documentary-style film. (19 mins)
ANIMATION
Lives behind slides
This short animation depicts patients with breast cancer, whose lives are impacted by their HER2 status. (2 mins)
MICROSCOPY SERIES
Microscopy review:
Slide validation
Dr. Bui discusses specimen requirements and recommendations to reduce pre-analytical variables. (17 mins)
MICROSCOPY SERIES
Microscopy review:
Approaching the scoring
Dr. Tozbikian demonstrates current approaches to HER2 IHC scoring. (17 mins)
MICROSCOPY SERIES
Microscopy review: Areas of diagnostic pitfalls
Dr. Hicks highlights considerations when interpreting HER2 status. (19 mins)
MICROSCOPY SERIES
Microscopy review: Correlating interpretation with clinical history
Dr. Feldman discusses histopathologic findings in view of the clinical background. (15 mins)
E-LEARNING
From past to present: The significance of HER2 in breast cancer
In the first session of this three-part program, Dr. Wei explores the spectrum of HER2 expression with slide reviews from Dr. Krishnamurthy and Dr. Wen. (48 mins)
E-LEARNING
Consistency with practice: Standardizing the approach to HER2 IHC scoring
Dr. Hicks discusses the importance of pre-analytic, analytic, and post-analytic variables. Dr. Khoury and Dr. Tozbikian review artifacts and indeterminate staining patterns. (57 mins)
E-LEARNING
Challenge accepted: Best practices for scoring HER2 across the spectrum
Dr. Jaffer provides guidance on recognition of HER2 staining patterns and heterogeneity. Dr. Krishnamurthy and Dr. Bui present challenging HER2 IHC cases. (60 mins)
E-LEARNING
Interpreting HER2 in breast cancer: USCAP course summary
Summary documents of the USCAP e-learning program Interpreting HER2 in breast cancer: A full spectrum of possibilities.
DOCUMENTARY
The significance of HER2: Trailer
A short preview of a mini documentary-style film presented by Dr. Marilyn Bui and Dr. Hope S. Rugo. (2 mins)
E-LEARNING
Topic 1: Clinical innovation across the HER2 pathway
Dr. Krishnamurthy presents the evolution of HER2 in clinical practice. (7 mins)
E-LEARNING
Topic 2: The spectrum of HER2 expression
Dr. Tozbikian reviews current HER2 guidelines and the significance of discrete HER2 IHC scoring. (9 mins)
E-LEARNING
Topic 3: Overcoming challenges in assessing HER2 expression across the spectrum
Dr. Hicks highlights best clinical practices for differentiating low levels of HER2. (11 mins)
MICROSCOPY SERIES
Microscopy review:
Slide validation
Dr. Bui discusses specimen requirements and recommendations to reduce pre-analytical variables. (17 mins)
MICROSCOPY SERIES
Microscopy review:
Approaching the scoring
Dr. Tozbikian demonstrates current approaches to HER2 IHC scoring. (17 mins)
MICROSCOPY SERIES
Microscopy review: Areas of diagnostic pitfalls
Dr. Hicks highlights considerations when interpreting HER2 status. (19 mins)
MICROSCOPY SERIES
Microscopy review: Correlating interpretation with clinical history
Dr. Feldman discusses histopathologic findings in view of the clinical background. (15 mins)
E-LEARNING
From past to present: The significance of HER2 in breast cancer
In the first session of this three-part program, Dr. Wei explores the spectrum of HER2 expression with slide reviews from Dr. Krishnamurthy and Dr. Wen. (48 mins)
E-LEARNING
Consistency with practice: Standardizing the approach to HER2 IHC scoring
Dr. Hicks discusses the importance of pre-analytic, analytic, and post-analytic variables. Dr. Khoury and Dr. Tozbikian review artifacts and indeterminate staining patterns. (57 mins)
E-LEARNING
Challenge accepted: Best practices for scoring HER2 across the spectrum
Dr. Jaffer provides guidance on recognition of HER2 staining patterns and heterogeneity. Dr. Krishnamurthy and Dr. Bui present challenging HER2 IHC cases. (60 mins)
E-LEARNING
Interpreting HER2 in breast cancer: USCAP course summary
Summary documents of the USCAP e-learning program Interpreting HER2 in breast cancer: A full spectrum of possibilities.
ALGORITHM
Algorithmic approach to standardizing HER2 scoring
Dr. Hicks shares his approach for scoring HER2 by IHC.
GUIDE
HER2 IHC scoring resource and guide
A summarized approach to HER2 IHC interpretation, based on most recent guidelines and expert opinion.
GUIDE
HER2 differentiation in practice: a quick visual guide
An in-lab visual reference for recognizing HER2 IHC staining patterns to assist clinical practice.
GUIDE
HER2 expression in breast cancer: A comprehensive reference
A downloadable comprehensive guide to HER2 IHC scoring.
ANIMATION
Recognizing HER2 staining patterns at the low end of the spectrum
A short animation, discussing best practice recommendations for scoring HER2 by IHC with Dr. Feldman. (4 mins)
ANIMATION
Identifying Low Levels of HER2 Expression in Breast Cancer
Short animation which describes CAP’s 2023 updated reporting template for HER2-low breast cancer and best practices for pathologists when reviewing these cases. (1.5 mins)
MICROSCOPY SERIES
Microscopy review:
Slide validation
Dr. Bui discusses specimen requirements and recommendations to reduce pre-analytical variables. (17 mins)
MICROSCOPY SERIES
Microscopy review:
Approaching the scoring
Dr. Tozbikian demonstrates current approaches to HER2 IHC scoring. (17 mins)
MICROSCOPY SERIES
Microscopy review: Areas of diagnostic pitfalls
Dr. Hicks highlights considerations when interpreting HER2 status. (19 mins)
MICROSCOPY SERIES
Microscopy review: Correlating interpretation with clinical history
Dr. Feldman discusses histopathologic findings in view of the clinical background. (15 mins)
E-LEARNING
From past to present: The significance of HER2 in breast cancer
In the first session of this three-part program, Dr. Wei explores the spectrum of HER2 expression with slide reviews from Dr. Krishnamurthy and Dr. Wen. (48 mins)
E-LEARNING
Consistency with practice: Standardizing the approach to HER2 IHC scoring
Dr. Hicks discusses the importance of pre-analytic, analytic, and post-analytic variables. Dr. Khoury and Dr. Tozbikian review artifacts and indeterminate staining patterns. (57 mins)
E-LEARNING
Challenge accepted: Best practices for scoring HER2 across the spectrum
Dr. Jaffer provides guidance on recognition of HER2 staining patterns and heterogeneity. Dr. Krishnamurthy and Dr. Bui present challenging HER2 IHC cases. (60 mins)
E-LEARNING
Interpreting HER2 in breast cancer: USCAP course summary
Summary documents of the USCAP e-learning program Interpreting HER2 in breast cancer: A full spectrum of possibilities.
ALGORITHM
Algorithmic approach to standardizing HER2 scoring
Dr. Hicks shares his approach for scoring HER2 by IHC.
GUIDE
HER2 IHC scoring resource and guide
A summarized approach to HER2 IHC interpretation, based on most recent guidelines and expert opinion.
GUIDE
HER2 differentiation in practice: a quick visual guide
An in-lab visual reference for recognizing HER2 IHC staining patterns to assist clinical practice.
GUIDE
HER2 expression in breast cancer: A comprehensive reference
A downloadable comprehensive guide to HER2 IHC scoring.
ANIMATION
Recognizing HER2 staining patterns at the low end of the spectrum
A short animation, discussing best practice recommendations for scoring HER2 by IHC with Dr. Feldman. (4 mins)
ANIMATION
Identifying Low Levels of HER2 Expression in Breast Cancer
Short animation which describes CAP’s 2023 updated reporting template for HER2-low breast cancer and best practices for pathologists when reviewing these cases. (1.5 mins)
GUIDELINES
CAP quantitative image analysis (QIA) guidelines
Recommendations for optimizing interpretation of HER2 IHC performed by QIA in breast cancer.
GUIDELINES
ASCO-CAP HER2 testing guidelines
Recommendations for improving accuracy and standardization of HER2 testing in breast cancer. In 2023, ASCO-CAP published a guideline update, which affirmed the guidelines provided here.
GUIDELINES
CAP quantitative image analysis (QIA) guidelines
Recommendations for optimizing interpretation of HER2 IHC performed by QIA in breast cancer.
GUIDELINES
ASCO-CAP HER2 testing guidelines
Recommendations for improving accuracy and standardization of HER2 testing in breast cancer. In 2023, ASCO-CAP published a guideline update, which affirmed the guidelines provided here.
CAP, College of American Pathologists; HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; USCAP, United States and Canadian Academy of Pathology.
1. Wolff AC, et al. Arch Pathol Lab Med 2023. https://doi.org/10.5858/arpa.2023-0950-SA.