UNDERLYING MECHANISM OF CKD
When CKD is left unchecked, kidney function continues to decline.2,14 Here’s why.
Inside the kidneys,
pressure is building
While patients may experience no early symptoms of CKD, inside their kidneys, intraglomerular pressure is building.2,14
As intraglomerular pressure builds, it slowly destroys nephrons, leading to progressive damage and reduced kidney function.2,3,14
INSIDE THE KIDNEYS,
PRESSURE IS BUILDING
LOOK INSIDE
INSIDE THE KIDNEYS,
PRESSURE IS BUILDING
Inside the kidneys,
pressure is building
While patients may experience no early symptoms of CKD, inside their kidneys, intraglomerular pressure is building.2,14
As intraglomerular pressure builds, it slowly destroys nephrons, leading to progressive damage and reduced kidney function.2,3,14
CKD, chronic kidney disease; CV, cardiovascular; eGFR, estimated glomerular filtration rate; GFR, glomerular filtration rate.
References
- Ryan TP et al. Am J Med. 2007;120(11):981–986.
- Ravera M et al. Am J Kidney Dis. 2011;57(1):71–77.
- GBD Chronic Kidney Disease Collaboration, Lancet. 2020;395(10225):709–733.
- Alabama Department of Public Health. Special Task Force on Chronic Kidney Disease report. April 2007. Accessed 20 November 2020.
https://www.alabamapublichealth.gov/publications/assets/kidneydiseasereport.pdf - Kidney Disease: The Basics. National Kidney Foundation. Published May 2020. Accessed 20 November 2020.
https://www.kidney.org/news/newsroom/factsheets/KidneyDiseaseBasics - Brenner BM et al. N Engl J Med. 2001;345(12):861–869.
- Go AS et al. N Engl J Med. 2004;351(13):1296–1305.
- Estimated glomerular filtration rate (eGFR). National Kidney Foundation. Reviewed 14 September 2020. Accessed 25 November 2020.
https://www.kidney.org/atoz/content/gfr - Ghaderian SB et al. J Renal Inj Prev. 2014;3(4):109–110.
- Courser WG et al. Kidney Int. 2011;80(12):1258–1270.
- Chronic kidney disease basics. Centers for Disease Control and Prevention. Page reviewed 7 February 2020. Accessed 6 October 2020.
https://www.cdc.gov/kidneydisease/basics.html - Kidney Disease Stats. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. December 2016. Accessed 25 November 2020.
https://www.niddk.nih.gov/health-information/health-statistics/kidney-disease - Yacoub R, Habib H, Lahdo A, et al. Association between smoking and chronic kidney disease: A case control study. BMC Public Health. 2010;10:731.
- Schnaper HW. Pediatr Nephrol. 2014;29(2):193–202.