Human biological samples

Interrogate complex disease biology from human clinical samples

Working together to discover novel insights from human biological samples  

We are always learning from people who live with the diseases our medicines treat so we can understand their needs and make sure that great science born in the lab can make a real difference to their lives. We are looking to collaborate with researchers with human samples collected from clinical studies that are suitable for data generation and analysis.

Our commitment to diversity and sustainability means developing medicines for all patients. In order to do that, we want to access samples from diverse genetic backgrounds to ensure we can treat patients no matter where they are from. By analysing these samples together, we can learn more about disease biology and uncover potential therapeutic targets at a pace that may not otherwise be possible.  

For more information on our strategic areas of interest, please see here.

Programme details

Submission status: Currently not accepting proposals

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Configure Accordion Item: - What are we looking for?
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Configure Accordion Item: - What are we looking for?

While we consider all submissions, we are particularly interested in samples relevant to our strategic areas of interest listed below. Sample sets should contain at least 100 samples and have informed consent that allows them to be shared. We are particularly interested in samples that have complementary analyses, e.g. imaging or multi-omics analyses.   

Configure Accordion Item: - Benefits
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By collaborating with us, you will gain access to a broad range of analytical methods, including genome sequencing, RNAseq, proteomics, metabolomics and a novel multi-omics integration pipeline. By using these methods, we can generate data from your samples with a speed and quality that may otherwise be hard to achieve. 

Configure Accordion Item: - Who is this for?
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Configure Accordion Item: - Who is this for?

This programme is open to basic and applied researchers with appropriate patient samples, the ability to share them, and utilise the data generated. 

Configure Accordion Item: - How to apply
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Configure Accordion Item: - How to apply

In order to request to share samples with us, please send an email to openinnovation@astrazeneca.com and provide the following information:

  • A description of the samples that you have including the type of sample, the study from which it was derived and the number of samples
  • A copy of the informed consent
  • An indication of the type of analysis that has already been performed on these samples
  • A desired analysis you would like performed on the samples

Strategic areas of interest

 

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FAQs

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Configure Accordion Item: - What is AstraZeneca’s view on intellectual property?
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Configure Accordion Item: - What is AstraZeneca’s view on intellectual property?

Our Open Innovation programmes are based on mutual trust and reward innovation, including in the context of intellectual property (IP) rights. If a collaboration is agreed, the party that has pre-existing IP, or generates IP, will retain their rights on the target or approach. However, we would expect first right of negotiation to in-license the lead series derived from projects in which our compound libraries are screened. 

Configure Accordion Item: - What funding opportunities does AstraZeneca provide for studies that use molecules from the AstraZeneca library?
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Configure Accordion Item: - What funding opportunities does AstraZeneca provide for studies that use molecules from the AstraZeneca library?

We do not typically provide funding for collaborations using AstraZeneca molecules or libraries. However, we provide sufficient AstraZeneca molecules to enable research studies as well as access to necessary data to support experiment design and interpretation of results. We will also provide a letter of support to accompany a funding application. 

Configure Accordion Item: - How do I know that the information I submit to AstraZeneca will remain confidential?
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Configure Accordion Item: - How do I know that the information I submit to AstraZeneca will remain confidential?

We are committed to the same ethical policies that are practiced during grant and manuscript peer-reviews. We will not use or disclose information you submit, unless you approve in writing, or the information becomes public, is separately received or independently developed. 

Configure Accordion Item: - What are the typical agreement terms?
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Configure Accordion Item: - What are the typical agreement terms?

Our Open Innovation programme supports agreement terms that facilitate participation, open collaborative brainstorming and problem solving, and are consistent with well-established and tested academic-industry agreement structures. While the terms and conditions of the collaboration are determined on a case by case basis with your organisation, broadly applicable terms and conditions include:  

  • Pre-existing IP retained with the original owner
  • New IP follows ownership framework taking into account the contribution of each party and where possible using the well-established academic-industry templates
  • Publications are encouraged after allowing AstraZeneca to comment
  • Patent(s) are encouraged to be filed (if applicable), with AstraZeneca confidential information remaining protected
  • If the collaboration generates positive findings, AstraZeneca has an option to negotiate a license to further advance the findings towards positive patient benefits and commercialisation
  • For compounds ‘live’ in development, AstraZeneca minimally receives non-exclusive, royalty-free, fully paid license, with the right to sublicense without limitation, for all purposes for project IP

In general, Collaborative Research Agreement (CRA) and/or Clinical Trial Agreement (CTA) are/is negotiated for an agreed upon Full Project Proposal/Plan. 

  • Ownership of project IP and rewards (e.g. royalties) if positive data found are based on multiple factors including regional/country standards, IP policies and the current development stage/status of the compound 
  • AstraZeneca has at least an option to negotiate a license for project IP

Still have a question?

 

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