Clinical molecules

Search for the next novel clinical agent to advance your research

Submit a proposal and help drive innovative science

We provide the molecule, you unlock the potential

Our teams have developed a library of clinic-ready molecules demonstrating target engagement and tolerability through Phase 2 research. We are looking to share our molecules with researchers who have innovative ideas for expanding their use across novel disease targets and expanding the reach to patients that could benefit from them.

To date, 34 investigator-sponsored clinical studies supported by Open Innovation have received approval, and 16 have successfully completed. Could your proposal be the next success?

Programme details

Submission status: Active

No submission deadline, please apply any time.  

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Configure Accordion Item: - What are we looking for?
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Configure Accordion Item: - What are we looking for?

We are looking for proposals to test our molecules in clinical indications that they have not previously been tested in. Proposals should contain clearly defined goals that would allow further development of the molecule, rather than exploratory studies.   

Configure Accordion Item: - Benefits
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Configure Accordion Item: - Benefits

In collaborating with us on your clinical study, we will provide: 

  • The study drug 
  • Documentation supporting regulatory filings 
  • Maintenance of drug safety databases  
  • Patient safety monitoring    

We typically do not provide funding to support this work, but we will provide a letter of support for you to include in your grant funding application. 

Configure Accordion Item: - Who is this for?
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Configure Accordion Item: - Who is this for?

This programme is open to researchers and physicians engaged in clinical research within an academic setting, and from any geographic region. Start-ups and biotechs are out of scope for this programme. 

Configure Accordion Item: - How to apply
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Configure Accordion Item: - How to apply

Application Process

Clinical molecules 

Submit a proposal and help drive innovative science

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FAQs

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Configure Accordion Item: - What is AstraZeneca’s view on intellectual property?
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Configure Accordion Item: - What is AstraZeneca’s view on intellectual property?

Our Open Innovation programmes are based on mutual trust and reward innovation, including in the context of intellectual property (IP) rights. If a collaboration is agreed, the party that has pre-existing IP, or generates IP, will retain their rights on the target or approach. However, we would expect first right of negotiation to in-license the lead series derived from projects in which our compound libraries are screened. 

Configure Accordion Item: - What funding opportunities does AstraZeneca provide for studies that use molecules from the AstraZeneca library?
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Configure Accordion Item: - What funding opportunities does AstraZeneca provide for studies that use molecules from the AstraZeneca library?

We do not typically provide funding for collaborations using AstraZeneca molecules or libraries. However, we provide sufficient AstraZeneca molecules to enable research studies as well as access to necessary data to support experiment design and interpretation of results. We will also provide a letter of support to accompany a funding application. 

Configure Accordion Item: - How do I know that the information I submit to AstraZeneca will remain confidential?
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Configure Accordion Item: - How do I know that the information I submit to AstraZeneca will remain confidential?

We are committed to the same ethical policies that are practiced during grant and manuscript peer-reviews. We will not use or disclose information you submit, unless you approve in writing, or the information becomes public, is separately received or independently developed. 

Configure Accordion Item: - What are the typical agreement terms?
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Configure Accordion Item: - What are the typical agreement terms?

Our Open Innovation programme supports agreement terms that facilitate participation, open collaborative brainstorming and problem solving, and are consistent with well-established and tested academic-industry agreement structures. While the terms and conditions of the collaboration are determined on a case by case basis with your organisation, broadly applicable terms and conditions include:  

  • Pre-existing IP retained with the original owner
  • New IP follows ownership framework taking into account the contribution of each party and where possible using the well-established academic-industry templates
  • Publications are encouraged after allowing AstraZeneca to comment
  • Patent(s) are encouraged to be filed (if applicable), with AstraZeneca confidential information remaining protected
  • If the collaboration generates positive findings, AstraZeneca has an option to negotiate a license to further advance the findings towards positive patient benefits and commercialisation
  • For compounds ‘live’ in development, AstraZeneca minimally receives non-exclusive, royalty-free, fully paid license, with the right to sublicense without limitation, for all purposes for project IP

In general, Collaborative Research Agreement (CRA) and/or Clinical Trial Agreement (CTA) are/is negotiated for an agreed upon Full Project Proposal/Plan. 

  • Ownership of project IP and rewards (e.g. royalties) if positive data found are based on multiple factors including regional/country standards, IP policies and the current development stage/status of the compound 
  • AstraZeneca has at least an option to negotiate a license for project IP

Still have a question?

 

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