/*css start*/
.study-design #body-copy, .study-design #tab-section, .study-design #tab-section, .study-design #foot-ref-mgwid   {
    margin: 0px auto 0;
    max-width: 1190px;
    width: 100%;
}
.study-design .study-timeline {
    display: flex;
    flex-direction: column;
}
.study-design .study-timeline h2 {
    margin: 0;
    font-size: 24px;
    color: #1C1C1C;
    font-family: 'Lexend', sans-serif;
    font-weight: 600;
    line-height: normal;
}
.study-design .study-timeline-img {
        width: 100%;
        max-width: 1133px;
    }
.study-design .study-timeline-img {
    padding: 32px 0;
} 
    .d-mobile {
        display: none;
    }
.study-design #greenbar-callout {
    padding: 0 0 32px;
}
.study-design #greenbar-callout div p
 {
    font-size: 18px;
}
#greenbar-callout div p {
    color: #004122;
    font-family: 'Lexend', sans-serif;
    font-weight: 600;
    font-size: 20px;
    padding: 12px 0;
    text-align: center;
}
.study-design #greenbar-callout div {
    width: unset;
    max-width: 1133px;
    margin: unset;
}
.study-design #greenbar-callout div {
    max-width: 1160px;
    margin: 0 auto;
    background-color: #E5F0EB;
    border-radius: 5px;
}
.study-design #footnotes {
        margin-bottom: 60px;
    }
    blockquote, dd, dl, dt, h1, h2, h3, h4, h5, h6, li, ol, p, ul {
    margin: 0;
}
.study-design #text-a18113338b .footnote-content p {
    padding-left: unset;
}
.footnote-fnts, .footnote-content p {
    color: #000;
    font-family: "Britanica-Regular";
    font-size: 14px;
    font-weight: 400;
    line-height: normal;
    text-indent: -4px;
    padding-left: 4px;
}
.study-design #footnotes ol li:nth-of-type(1) {
    margin-bottom: 0;
}
.wainua-tabs .litab-list-element.active {
    z-index: 1;
    background: white;
    box-shadow: 3px -2px 3px 0px #00000014, -3px -2px 3px 0px #0000000f;
    color: #004122 !important;
    font-weight: 700;
    border-radius: 5px 5px 0 0;
    position: relative;
    overflow: hidden;
}

.wainua-tabs li.tab-list-element.active {
    z-index: 1;
    background: white;
    box-shadow: 3px -2px 3px 0px #00000014, -3px -2px 3px 0px #0000000f;
    color: #004122;
    font-weight: 700;
    border-radius: 5px 5px 0 0;
    position: relative;
    overflow: hidden;
}

.wainua-tabs ul.nav.nav-pills.tab-list li:not(:last-child) {
    margin-right: 15px;
}

.wainua-tabs li.tab-list-element, li.tab-list-element.active {
    font-size: 18px;
    line-height: normal;
}

.wainua-tabs ul.nav.nav-pills.tab-list li {
    width: 250px;
}
.wainua-tabs li.tab-list-element {}

.wainua-tabs li.tab-list-element {
    padding: 20px 16px 0;
    margin-right: 16px;
}

.wainua-tabs li.tab-list-element {
    border-radius: 5px 5px 0 0;
    background: #e2e2e2;
    color: #000;
    text-align: center;
    font-family: 'Lexend', sans-serif;
    font-style: normal;
    font-weight: 500;
    width: 250px;
    border-bottom: 0;
    height: 60px;
}

.wainua-tabs li.tab-list-element.active::before {
    content: "";
    position: absolute;
    top: 0;
    left: 0;
    width: 100%;
    height: 5px;
    background: linear-gradient(to left, #F26522, #FFEF44);
    z-index: 2;
}
.wainua-tabs .nav>li>a {
    position: relative;
    display: block;
    padding: 0;
}
.wainua-tabs .nav-pills>li.active>a, .wainua-tabs .nav-pills>li.active>a:focus, .wainua-tabs .nav-pills>li.active>a:hover {
    background: transparent;
    border-bottom: 0;
    color:#004122;
    font-family: 'Lexend';
    font-size: 18px;
    font-weight: 700;
}
.wainua-tabs .nav-pills>li>a:hover, .wainua-tabs .nav-pills>li.active>a:hover {
    background: transparent;
    border-bottom: 0;
    text-decoration: none;
}
.study-design .nav-pills {
    border-bottom: 0px solid #ddd;
    margin-bottom: 0px;
}
    .study-design .wainua-tabs .tabs-container {
        background: #FFFFFF 0% 0% no-repeat padding-box;
        box-shadow: 0px -1px 12px #00000029;
        opacity: 0.9;
    }
.wainua-tabs-content {
    display: flex;
    flex-direction: column;
    width: 90%;
    margin: 0 auto;
}
    .study-design .wainua-tabs-content .intro-text {
        padding: 32px 0;
        margin-bottom: 0;
    }
    .study-design .wainua-tabs-content .intro-text, .study-design .endopoint-category {
    color: #006838;
}
.study-design .wainua-tabs-content .tab-title-txt.endopoint-category {
    font-size: 20px;
    font-weight:600;
}
.study-design .study-timeline .heading, .study-design .patient-types .patient-types-content .intro-title, .study-design .wainua-tabs-content .intro-text, .study-design .endopoint-category, .study-design .PT-item .PT-item-title {
    font-weight: 600;
}
.study-design .wainua-tabs-content .endpoint-item .desc, .study-design .PT-item .PT-item-desc {
    font-weight: 400;
}
.study-design .belowImg, .study-design .wainua-tabs-content .intro-text, .study-design .endopoint-category, .study-design .wainua-tabs-content .endpoint-item .title, .study-design .wainua-tabs-content .endpoint-item .desc {
    font-style: normal;
    line-height: normal;
}
.study-design .endopoint-category, .study-design .wainua-tabs-content .endpoint-item .title, .study-design .wainua-tabs-content .endpoint-item .desc, .study-design .PT-item .PT-item-desc, .study-design .PT-item .PT-item-title {
    font-family: Lexend;
}
.ta-center {
    text-align: center;
    font-style:normal;
}
    .study-design .endopoint-category {
        font-size: 18px;
        margin-bottom: 16px;
    }
    .study-design .endopoint-category {
        width: 280px;
    }
    .study-design .wainua-tabs-content .endpoint-item .title, .study-design .wainua-tabs-content .endpoint-item .desc {
        font-size: 20px;
        color: #000;
    }
   .study-design .wainua-tabs-content .endpoint-item .title, .study-design .wainua-tabs-content .endpoint-item .desc, .study-design .patient-types .patient-types-content .intro-title, .study-design .patient-types .patient-types-content .intro-desc, .study-design .endopoint-category {
    text-align: center;
}
.study-design .wainua-tabs-content .endpoint-item .title {
    font-weight: 700;
}
    .study-design .PTgrid, .study-design .wainua-tabs-content .study-tabs-items-row {
        flex-direction: row;
    }
    .study-design .wainua-tabs-content .study-tabs-items-row {
    display: flex;
     flex-wrap: wrap; 
}
.study-design .wainua-tabs-content .endpoint-item .desc, .study-design .PT-item .PT-item-desc {
    font-weight: 400;
}
    .study-design .wainua-tabs-content .separator {
        background-color: #f26522;
        width: 2px;
        margin: 0 40px;
    }
    .study-design .endopoint-category:not(:first-of-type) {
    margin-top: 45px;
}
.study-design .endopoint-category {
        font-size: 18px;
        margin-bottom: 16px;
        
    }
    .study-design .wainua-tabs-content .intro-text, .study-design .endopoint-category {
    color: #006838;
}
.study-design .CTA-row {
    display: flex;
    justify-content: flex-end;
}
    .study-design .tabs-container.sd-tab1 .CTA-row-link, .study-design .tabs-container.sd-tab2 .CTA-row-link {
        padding: 0 10px 0 0;
        transform: translateY(-10px);
    }
        .study-design .CTA-row-link p {
        font-size: 20px;
        line-height: normal;
    }
    .study-design .CTA-row-link p {
    font-family: Lexend;
    font-weight: 700;
    font-style: normal;
    color: #1C1C1C;
    padding: 0;
    align-self: center;
}
 .study-design .CTA-row-link img.CTA-row-link-img,  .study-design .CTA-row-link:hover img.CTA-row-link-img-hover {
    display: block;
}
 .study-design .CTA-row-link img {
    width: 53px;
    height: 53px;
}
.study-design .CTA-row-link:hover img.CTA-row-link-img, .study-design .CTA-row-link img.CTA-row-link-img-hover {
    display: none;
}
.study-design .study-tabs-items-row .endpoint-item.w35-item {
        max-width: 282px;
    }
   .study-design .CTA-row-link {
    display: flex;
    gap: 16px;
    padding: 0 10px 10px 0;
}
.wainua-tabs .tabs-container {
    margin-bottom: 32px;
}
#tab-section {
    padding: 0;
}
.study-design #simple-card-columns .card-title {
    max-width: 445px;
    margin-top: 28px;
    margin-left: 30px;
    padding-right: 10px;
}
.endpoint-item.w85-item, .endpoint-item {
    max-width: 281px;
    width: 100%;
}
.study-design .wainua-tabs-content .tab-title-txt.endopoint-category {
    font-size: 18px;
    font-weight: 600;
    max-width: 90%;
    width: 100%;
    padding: 32px 0;
    margin: 0 auto;
    text-transform: uppercase;
}
#navbar .nav-menus > li:nth-child(3) > a {
    color: #006838;
    font-weight:700;
}
.study-design #navbar .nav-menus > li:nth-child(3) .dropdown_menu li:nth-child(1) a {
    color: #006838;
}
#navbar .dropdown_menu li:hover a {
    color: #fff !important;
}
.nav-pills>li>a {
    font-family: 'Lexend';
    color: #000000;
    font-size: 18px;
    font-weight: 500;
}
.study-design .CTA-row a {
    text-decoration: none !important;
}
.endpoint-item.w85-item {
    max-width: 250px;
}
#navbar .nav-menus > li:nth-child(3):after {
        content: "";
        position: absolute;
        background: linear-gradient(40deg, #F26522 -17.69%, #FFEF44 144.32%);
        display: inline-block;
        width: 100%;
        top: 69px;
        height: 5px;
    }

@media(max-width:992px){
   .study-design .study-timeline h2 {
    margin: 0;
    font-size: 20px;
   }
   .d-desktop {
    display: none;
}
.d-mobile {
    display: block;
}
.study-design .container {
    margin: 0px auto 0;
    max-width: 1160px;
    width: 100%;
}
.study-design #body-copy {
    margin: 0px auto 0;
    max-width: 1160px;
    width: 100%;
}
    .wainua-tabs li.cmp-tabs__tab {
        padding: 20px 5px 12px;
    }
    .wainua-tabs ul.nav.nav-pills.tab-list li {
        max-width: 107px;
        width: 100%;
    }
        .wainua-tabs ul.nav.nav-pills.tab-list li:last-child {
        margin-right: 0;
    }
        .wainua-tabs li.cmp-tabs__tab, .wainua-tabs li.cmp-tabs__tab.cmp-tabs__tab--active {
        font-size: 16px;
        line-height: 22.5px;
        }
        ul.nav.nav-pills.tab-list {
    display: flex;
}
.tab-container[data-enable-mobile-horizontal="true"] .tab-list .tab-list-element.active a {
        border-left: 0;
        border-bottom: 0;
    }
        .wainua-tabs-content {
        max-width: 400px;
        width: 90%;
        margin:0 auto;
    }
    .study-design .wainua-tabs-content .study-tabs-items-row {
        flex-direction: column;
        margin: auto;
    }
    .study-design .endopoint-category {
        margin-bottom: 16px;
    }
    .study-design .wainua-tabs-content .endpoint-item .title, .study-design .wainua-tabs-content .endpoint-item .desc {
        font-size: 18px;
        margin: auto;
    }
        .study-design .tabs-container .CTA-row .CTA-row-link {
        padding: 0 0 30px 0;
    }
    .study-design .CTA-row-link {
        justify-content: center;
        margin: 0 auto;
    }
    .study-design .wainua-tabs-content .tab-title-txt.endopoint-category {
         font-weight: 600;
        max-width: 208px;
        width: 100%;
        margin: 0 auto;
        padding: 15px 0 20px;
        font-size: 16px;
        align-self: center;
}
    .study-design .wainua-tabs-content .separator {
        background-color: #f26522;
        width: 100%;
        height: 2px;
        margin: 25px 0;
    }
    .study-design .wainua-tabs-content .study-tabs-items-row:last-of-type {
        margin-bottom: 25px;
    }
    .wainua-tabs .tabs-container {
    margin-bottom: 40px;
}
  .study-design .tab-container {
        margin: 0px 0px 0px;
        padding-top: 0;
        border-top: 0px solid #ccc;
    }
    #isi-section .isi-content p br {
    display: none;
}
.study-design .endopoint-category {
        font-size: 16px;
        margin-bottom: 16px;
       margin-left: auto;
    margin-right: auto;
    }
    .study-design .wainua-tabs-content .tab-title-txt.endopoint-category.mob-tab {
    max-width: 300px;
    width: 100%;
    margin-left: auto;
    margin-right: auto;
}
#footnode-container .footnodelist {
    padding-left: 1px;
    list-style: decimal;
    margin-bottom: 0;
    font-family: "Britanica-Regular";
    color: #000000;
    font-size: 18px;
    font-weight: 700;
}
#greenbar-callout div p {
    color: #004122;
    font-family: 'Lexend', sans-serif;
    font-weight: 600;
    font-size: 18px;
    padding: 12px 10px;
    text-align: center;
}
.wainua-tabs li.tab-list-element {
    padding: 16px 7px 0;
    margin-right: 15px;
}
.study-design .CTA-row-link p {
    font-size: 18px;
    line-height: normal;
}
}
@media (max-width: 767px) {
    #subpage-topBanner {
        padding: 24px 0 24px;
    }
    .study-design #footnotes {
    margin-bottom: 32px;
}
span.sm-line {
    white-space: nowrap;
}
.endpoint-item.w85-item {
    max-width: 281px;
}
}
@media(max-width:450px){
    
}